Wednesday, December 26, 2012

JIPMER - Forensic Medicine

Generally Jipmer questions will be easy. So i am giving only few questions for quiz. Below are the topics asked previously.

Ponds # - skull # seen in children
Cadaveric spasm
IPC 320
Pugilistic attitutde - burns
Postmortem caloricity
Clavicle - first ossification
Leading questions are NOT asked in examination in chief
Rigor mortis first develops in orbicularis muscle


Monday, May 14, 2012

zurker




Just click here and connect with me in the new revolutionary 
social networking site - Zurker

Thursday, May 10, 2012

Wednesday, May 2, 2012

Various Random important facts


HIGH YIELD FACTS

I prepared this notes for last minute preparation. But i can't study this in last minute due to stress. Friends, Read this and give your opinion. (caution: Various random important facts are given. There is no continuity)

Iodized salt:
Specific protection
production level 30 ppm
consumer level 15 ppm KI NaI
Neonatal Hypothyroidism - checking efficacy
______________________________________________________________

Lepromin test is a prognostic test. Positive in Tuberculoid leprosy. Indicates immunity.

Shick test positive in persons who are susceptible to Diphteria. Vaccination needed.

True or False only

Often Repeated Easy quesitons - season 2

Thursday, April 26, 2012

Myoglobin - High Yield Topic Series

Myoglobin

Myoglobin is abundant in muscles involved in laborious activity. Why ?

To know the answer, let's begin with some basics. 

Myoglobin contains only one polypeptide chain which contains only one Haem molecule. One Haem molecule can bind to only one O2 molecule.

Quaternary structure is possible only in the presence of >1 subunits in a protein. As Myoglobin is made up of a single polypeptide chain, Quaternary structure is NOT possible. As there is no Quaternary structure, Bohr effect, 2,3 BPG effect and co-operative effect are not possible. After all there is only one O2 in haem. So there is no role for co-operative effect. (As there is no co-operative effect, Oxygen dissociation curve of myoglobin is hyperbolic in shape)

Myoglobin has very high affinity for oxygen. Why ?
Myoglobin is NOT an Oxygen carrier. It is just an oxygen reservoir. Whenever the oxygen tension is  critically low in the myocyte it releases its Oxygen.

This is why Myoglobin is abundant in muscles with high activity.


Monday, April 23, 2012

Vit B12



Here are some high yield facts about vitamin B12.
  • Only water soluble vitamin stored in the body.  (other only's of special mention)
  •  Contains 2 C - Cobalt and Corrin ring  (other rings of biochemical importance) 
  • Present only in foods of animal origin (Curd is of animal origin!) So, pure vegans are prone to B12 defeciency (think of Gandhi)
 Though Intrinsic factor of castle is secreted by parietal cells of stomach, it can not bind to   B12  in the stomach. Why ?   B12  in the food is released by gastric juice and  B12 binds to cobalophilin, a salivary protein. In the duodenum, cobalophilin is hydrolysed --> IF binds to   B12 . Both gets absorbed in distal ileum.  
  •  Co-enzyme for 3 enzymes in the body - 1) Methyl malonyl CoA mutase 2)Methionine synthase  3) Leucine aminomutase.  (other 3's and 4's with exam point of view) 
  • Deficiency results in methyl malonyl  aciduria  (Xanthurenic acid - B6; FIGLU - folate)
  •  Folate is trapped in the form of  methyl THFA in B12  defeciency. 
  • Megaloblasts are NOT seen in peripheral smears. seen in bone marrow examination. You can see macrocytes in peripheral smear. 
  •  Cyanocobalamin is the synthetic form found in vitamin tablets. It releases negligible amounts of cyanide in the body.
I hope you know everything about pernecious anemia, blind loop syndrome etc.,

Injection  B12 is given for patients with diabetic neuropathy as it is important of myelin synthesis.

I am preparing an audio which contains more detail on the text given in Green. Keep visiting the blog for more updates. Leave your comments below.                                                                   

Wednesday, April 11, 2012

Biochemistry - part I - NEET pattern

AIPG 2007 - Radiology - 6 questions

AIPG 2010 - Dermatolgoy - 5 questions

AIPG 2011 - Orthopedics - just 5 repeat questions

AIPG 2010 - Anaesthesia just 4 questions

Monday, April 9, 2012

Inhibitors of Electron Transport Chain


Inhibitors of Electron Transport Chain

Most of the friends answered wrongly in the quiz. 
Don't forget ! Fo is not F zero. O is for Oligomycin. 

It is my duty to put a small note on ETC inhibitors as this topic is very important for exams. 

Amobarbital &  Rotenone  --> Complex I (NADH dehydrogenase-CoQ.)

Rotenone and MPTP (a neuro-toxin) --> Inhibits complex I and causes Parkinsons like features

Antimycin A - inhibits  --> Complex III (Q-cytochrome c oxidoreductase)


H2S,  CO & Cyanide --> inhibits complex IV (Cytochrome Oxidase)


Oligomycin --> inhibits Fo component of ATP synthase


Atractyloside --> inhibits Translocase 


Thermogenin --> brown adipose tissue,physiological uncoupler
Thyroxine


Dinitrophenol --> uncoupler


Discussion of Biochemistry - Carbohydrates part I - NEET pattern

Discussion of Biochemistry - Carbohydrates part I - NEET pattern


1. Inulin

Inulin is a homopolymer of fructose and contains least amount of glucose at the terminals.

As inulin is neither absorbed nor secreted in kidney, use for GFR estimation

Human enzymes can attack only alpha glycosidic linkage. As inulin and cellulose contain beta glycosidic linkage they are not digested. Cellulose is fermented by the help of intestinal bacteria. Pectin is neither digested nor fermented. 


2. Insulin Inhibits Glycogen Phosphorylase

Glycogen phosphorylase increases blood sugar. So insulin will inhibit it. This is easy. 

I want you to memorize this simple fact --> Whichever enzyme increases the blood glucose will be active in phosphorylated form.

3. Epimers

Epimers differ around a single carbon. Galactose is C4 epimer of glucose. Mannose is C2 epimer of glucose. Galactose and mannose are NOT epimers as they differ in more than one carbon
4 Girls  and 2 Man

I guess you know everything about rest of the questions. If you really want, inform me. 







Biochemistry - Amino Acids part I - NEET pattern


 Keep revising ! Revision is the KEY to success !

Saturday, April 7, 2012

Prepare for PGI entrance - for Beginners



PGIMER (Post Graduate Institute of Medical Education and Research), Chandigarh  conducts entrance exams in the months of November and May each year.

NEET/CET won't cover AIIMS, PGIMER, JIPMER, NIMHANS and other Institutes of National importance.

As there is no MBBS course in PGI, postgraduate students in basic science and para-clinical departments can concentrate more in research. This is a golden opportunity indeed!

PGI Exam contains 250 questions. Each question contains 5 possible answers. Single correct answer, Multiple correct answers & No correct answer are possible. The worst thing is you have to shade more than one circle and it takes lot of time too.


Number of questions in each subject as given in prospectus:
Applied Anatomy - 6 
Applied Biochemistry-12
Immunogenetic & Molecular Biology-10
Applied Physiology- 6
Pa t h o l o g y - 1 5
Ph a r m a c o l o g y - 1 2
M i c r o b i o l o g y - 1 2
Fo r e n s i c M e d i c i n e - 6
          S o c i a l &Preventive Medicine-7
Medicine-36
Paediatrics-12
Dermatology-6
Psychiatry-6
Radiodiagnosis-6
Radiotherapy-6
Surgery-36
ENT-10
Orthopaedics -10
          Ophthalmology-10
Anaesthesia-6
Obst & Gynaecology-20.
Subjects having highest weightage are highlighted. Concentrate on these subjects.